Apocalypse was an insane force of destruction, sometimes described as the personification of evil. He was a nearly invincible opponent, with a Juggernaut-like state of durability. He showed no known limitations to his power and knowledge, and claimed to be "as far beyond mutants as they are beyond humans". Apocalypse attempted to destroy and remake the "corrupt" and "weak" world in his own image. He was secretly behind the assassination attempt of Senator Kelly. Later, he masqueraded as a member of the friends of Humanity and used Graydon Creed in creating a virus to infect and kill every mutant on Earth.
Archangel, his former Horseman became hell-bent on destroying Apocalypse, and discovered that the immortal mutant in fact had a weakness, though this was discovered to be a hoax, created by Apocalypse himself.
When New York was destroyed by radiation in the Oscorp disaster, most super-powered beings perished. Apocalypse saw this as an easy opportunity for him to claim world domination, as most humans in North America were being poisoned by the released radiation. Apocalypse quickly occupied the country, and with his growing legion of minions he declared war on the rest of the world.
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