Cable was part of a resistance team battling against Apocalypse in 3999 A.D. Reality began to replace itself after overlapping with a timeline where Bishop altered an important event in history. Cable discovered this, and managed to travel to the past before being replaced along with his reality.
In the past, Cable tried to stop Bishop from preventing the release of a plague, which was crucial to Cable's timeline. However, the plague was destroyed, although Cable managed to create the antibodies needed for the survival of the mutant race in his reality.
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